Nous savons déjà que les intestins ont leur propre système nerveux, le SNE (système nerveux entérique), qui compte plus de 500 millions de neurones. Les scientifiques étudient à présent la manière dont les cellules nerveuses du SNE communiquent avec les neurones du cerveau à travers l’« axe intestin-cerveau ». Les dernières recherches sur le sujet montrent que tout ce qui se produit dans le milieu intestinal, y compris l’activité des bactéries qui y résident, influence les actions des neurones du SNE.

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Références :

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Zhou L, Foster JA. Psychobiotics and the gut–brain axis: in the pursuit of happiness. Neuropsychiatric Disease and Treatment. 2015; 11: 715–723. doi https://dx.doi.org/10.2147/NDT.S61997

Kunze WA, Mao Y, Wang B, et al. Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J. Cell. Mol. Med. 2009; 13(8B): 2261-2270. doi:10.1111/j.1582-4934.2009.00686.x

Forsythe P, Bienenstock J, Kunze WA. Vagal Pathways for Microbiome-Brain-Gut Axis Communication. In: Lyte M & Cryan JF, eds. Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. New York: Springer; 2014:115-133.

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Bercik P, Denou E, Collins J, Jackson W, et al. The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice. Gastroenterology. 2011; 141(2): 599-609. DOI: http://dx.doi.org/10.1053/j.gastro.2011.04.052

Li W, Dowd SE, Scurlock B, Acosta-Martinez V, Lyte M. Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria. Physiology & Behavior. 2009; 96(4-5); 557-567. doi:10.1016/j.physbeh.2008.12.004

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